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SIDRA

GXB

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Description

- Study Type: Natural Infection

Purpose

Using PAXgene tubes, peripheral blood samples were collected from seven patients >18 years with documented pdm(H1N1) influenza, bilateral chest infiltrates, and in need of ventilation support. Significant co-morbidity was exclusion criterion. Expression profiles were compared with 7 age matched controls. Using a false discovery rate < 5% and an absolute fold change > 2, 370 genes were differentially expressed in case and controls.A second sample was collected after ca 6 days in the 7 patients and temporal changes in expression profiles investigated. Over expressed putative mediators of inflammatory lung dammage were measured on the protein level.

Experimental Design

14 patient samples (7 paired samples) and 7 control samples were performed.

Platform Affymetrix HuGene 1.0 ST v1
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sampleset4000029_sampleannotations_Group.csv

sampleset4000029_sampleannotations_Group.csv

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