Sample Set Annotation Tool: Gene expression signatures of symptomatic respiratory viral infection in adults. GSE17156

Study Design
Assay
Sample Info
Files
Info
Samples
Group Sets
Analysis

Purpose

Diagnosis of acute respiratory viral infection is currentlybased on clinical symptoms and pathogen detection. Use of host peripheral blood gene expression data to classify individuals with viral respiratory infection represents a novel means of infection diagnosis.We used microarrays to capture peripheral blood gene expression at baseline and time of peak symptoms in healthy volunteers infected intranasally with influenza A H3N2, respiratory syncytial virus or rhinovirus. We determined groups of coexpressed genes that accurately classified symptomatic versus asymptomatic individuals.

Hypothesis

Experimental Design

We experimentally inoculated healthy volunteers with intranasal influenza, respiratory syncytial virus or rhinovirus. Symptoms were documented and peripheral blood samples drawn into PAXgene tubes for RNA isolation.

Experimental Variables

Controls

Methods

Additional Information

Expected Samples:

113 Samples Loaded: 113

Species

Human (Homo sapiens)

Sample Source

Whole Blood

Disease

Rhinovirus, RSV, influenza A N3N2

Treatment Protocol

Growth Protocol

Extraction Protocol

Storage Conditions

Sample Set Spreadsheet

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Samples Preview

Sample ID	!Sample Title	group	timepoint	Subject id	Symptom group
GSM429202	rhinovirus challenge sample at baseline_Rhino001	Rhinovirus at baseline	baseline	Rhino001	Asymptomatic
GSM429203	rhinovirus challenge sample at T_Rhino001	Rhinovirus at peak symptoms	T - peak symptoms	Rhino001	Asymptomatic
GSM429204	rhinovirus challenge sample at baseline_Rhino002	Rhinovirus at baseline	baseline	Rhino002	Asymptomatic
GSM429205	rhinovirus challenge sample at T_Rhino002	Rhinovirus at peak symptoms	T - peak symptoms	Rhino002	Asymptomatic
GSM429206	rhinovirus challenge sample at baseline_Rhino003	Rhinovirus at baseline	baseline	Rhino003	Symptomatic

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File
sampleset4000030_sampleannotations_Group.csv Sample Set Spreadsheet
sampleset4000030_sampleannotations_Group.csv Sample Set Spreadsheet

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Sample ID	!Sample Title	Group	Timepoint	Subject id	Symptom group
GSM429202	rhinovirus challenge sample at baseline_Rhino001	Rhinovirus at baseline	baseline	Rhino001	Asymptomatic
GSM429203	rhinovirus challenge sample at T_Rhino001	Rhinovirus at peak symptoms	T - peak symptoms	Rhino001	Asymptomatic
GSM429204	rhinovirus challenge sample at baseline_Rhino002	Rhinovirus at baseline	baseline	Rhino002	Asymptomatic
GSM429205	rhinovirus challenge sample at T_Rhino002	Rhinovirus at peak symptoms	T - peak symptoms	Rhino002	Asymptomatic
GSM429206	rhinovirus challenge sample at baseline_Rhino003	Rhinovirus at baseline	baseline	Rhino003	Symptomatic
GSM429207	rhinovirus challenge sample at T_Rhino003	Rhinovirus at peak symptoms	T - peak symptoms	Rhino003	Symptomatic
GSM429208	rhinovirus challenge sample at baseline_Rhino004	Rhinovirus at baseline	baseline	Rhino004	Symptomatic
GSM429209	rhinovirus challenge sample at T_Rhino004	Rhinovirus at peak symptoms	T - peak symptoms	Rhino004	Symptomatic
GSM429210	rhinovirus challenge sample at baseline_Rhino005	Rhinovirus at baseline	baseline	Rhino005	Asymptomatic
GSM429211	rhinovirus challenge sample at T_Rhino005	Rhinovirus at peak symptoms	T - peak symptoms	Rhino005	Asymptomatic
GSM429212	rhinovirus challenge sample at baseline_Rhino006	Rhinovirus at baseline	baseline	Rhino006	Symptomatic
GSM429213	rhinovirus challenge sample at T_Rhino006	Rhinovirus at peak symptoms	T - peak symptoms	Rhino006	Symptomatic
GSM429214	rhinovirus challenge sample at baseline_Rhino007	Rhinovirus at baseline	baseline	Rhino007	Symptomatic
GSM429215	rhinovirus challenge sample at T_Rhino007	Rhinovirus at peak symptoms	T - peak symptoms	Rhino007	Symptomatic
GSM429216	rhinovirus challenge sample at baseline_Rhino008	Rhinovirus at baseline	baseline	Rhino008	Asymptomatic
GSM429217	rhinovirus challenge sample at T_Rhino008	Rhinovirus at peak symptoms	T - peak symptoms	Rhino008	Asymptomatic
GSM429218	rhinovirus challenge sample at baseline_Rhino009	Rhinovirus at baseline	baseline	Rhino009	Symptomatic
GSM429219	rhinovirus challenge sample at T_Rhino009	Rhinovirus at peak symptoms	T - peak symptoms	Rhino009	Symptomatic
GSM429220	rhinovirus challenge sample at baseline_Rhino010	Rhinovirus at baseline	baseline	Rhino010	Asymptomatic
GSM429221	rhinovirus challenge sample at T_Rhino010	Rhinovirus at peak symptoms	T - peak symptoms	Rhino010	Asymptomatic
GSM429222	rhinovirus challenge sample at baseline_Rhino011	Rhinovirus at baseline	baseline	Rhino011	Symptomatic
GSM429223	rhinovirus challenge sample at T_Rhino011	Rhinovirus at peak symptoms	T - peak symptoms	Rhino011	Symptomatic
GSM429224	rhinovirus challenge sample at baseline_Rhino012	Rhinovirus at baseline	baseline	Rhino012	Asymptomatic
GSM429225	rhinovirus challenge sample at T_Rhino012	Rhinovirus at peak symptoms	T - peak symptoms	Rhino012	Asymptomatic
GSM429226	rhinovirus challenge sample at baseline_Rhino013	Rhinovirus at baseline	baseline	Rhino013	Asymptomatic
GSM429227	rhinovirus challenge sample at T_Rhino013	Rhinovirus at peak symptoms	T - peak symptoms	Rhino013	Asymptomatic
GSM429228	rhinovirus challenge sample at baseline_Rhino014	Rhinovirus at baseline	baseline	Rhino014	Asymptomatic
GSM429229	rhinovirus challenge sample at T_Rhino014	Rhinovirus at peak symptoms	T - peak symptoms	Rhino014	Asymptomatic
GSM429230	rhinovirus challenge sample at baseline_Rhino015	Rhinovirus at baseline	baseline	Rhino015	Symptomatic
GSM429231	rhinovirus challenge sample at T_Rhino015	Rhinovirus at peak symptoms	T - peak symptoms	Rhino015	Symptomatic
GSM429232	rhinovirus challenge sample at T_Rhino016	Rhinovirus at peak symptoms	T - peak symptoms	Rhino016	Symptomatic
GSM429233	rhinovirus challenge sample at baseline_Rhino017	Rhinovirus at baseline	baseline	Rhino017	Asymptomatic
GSM429234	rhinovirus challenge sample at T_Rhino017	Rhinovirus at peak symptoms	T - peak symptoms	Rhino017	Asymptomatic
GSM429235	rhinovirus challenge sample at baseline_Rhino018	Rhinovirus at baseline	baseline	Rhino018	Asymptomatic
GSM429236	rhinovirus challenge sample at T_Rhino018	Rhinovirus at peak symptoms	T - peak symptoms	Rhino018	Asymptomatic
GSM429237	rhinovirus challenge sample at baseline_Rhino019	Rhinovirus at baseline	baseline	Rhino019	Symptomatic
GSM429238	rhinovirus challenge sample at T_Rhino019	Rhinovirus at peak symptoms	T - peak symptoms	Rhino019	Symptomatic
GSM429239	rhinovirus challenge sample at baseline_Rhino020	Rhinovirus at baseline	baseline	Rhino020	Symptomatic
GSM429240	rhinovirus challenge sample at T_Rhino020	Rhinovirus at peak symptoms	T - peak symptoms	Rhino020	Symptomatic
GSM429241	respiratory syncytial virus challenge sample at baseline_RSV001	RSV at baseline	baseline	RSV001	Symptomatic
GSM429242	respiratory syncytial virus challenge sample at T_RSV001	RSV at peak symptoms	T - peak symptoms	RSV001	Symptomatic
GSM429243	respiratory syncytial virus challenge sample at baseline_RSV002	RSV at baseline	baseline	RSV002	Symptomatic
GSM429244	respiratory syncytial virus challenge sample at T_RSV002	RSV at peak symptoms	T - peak symptoms	RSV002	Symptomatic
GSM429245	respiratory syncytial virus challenge sample at baseline_RSV003	RSV at baseline	baseline	RSV003	Symptomatic
GSM429246	respiratory syncytial virus challenge sample at T_RSV003	RSV at peak symptoms	T - peak symptoms	RSV003	Symptomatic
GSM429247	respiratory syncytial virus challenge sample at baseline_RSV004	RSV at baseline	baseline	RSV004	Asymptomatic
GSM429248	respiratory syncytial virus challenge sample at T_RSV004	RSV at peak symptoms	T - peak symptoms	RSV004	Asymptomatic
GSM429249	respiratory syncytial virus challenge sample at baseline_RSV005	RSV at baseline	baseline	RSV005	Asymptomatic
GSM429250	respiratory syncytial virus challenge sample at T_RSV005	RSV at peak symptoms	T - peak symptoms	RSV005	Asymptomatic
GSM429251	respiratory syncytial virus challenge sample at baseline_RSV006	RSV at baseline	baseline	RSV006	Symptomatic
GSM429252	respiratory syncytial virus challenge sample at T_RSV006	RSV at peak symptoms	T - peak symptoms	RSV006	Symptomatic
GSM429253	respiratory syncytial virus challenge sample at baseline_RSV007	RSV at baseline	baseline	RSV007	Symptomatic
GSM429254	respiratory syncytial virus challenge sample at T_RSV007	RSV at peak symptoms	T - peak symptoms	RSV007	Symptomatic
GSM429255	respiratory syncytial virus challenge sample at baseline_RSV008	RSV at baseline	baseline	RSV008	Asymptomatic
GSM429256	respiratory syncytial virus challenge sample at T_RSV008	RSV at peak symptoms	T - peak symptoms	RSV008	Asymptomatic
GSM429257	respiratory syncytial virus challenge sample at baseline_RSV009	RSV at baseline	baseline	RSV009	Asymptomatic
GSM429258	respiratory syncytial virus challenge sample at T_RSV009	RSV at peak symptoms	T - peak symptoms	RSV009	Asymptomatic
GSM429259	respiratory syncytial virus challenge sample at baseline_RSV010	RSV at baseline	baseline	RSV010	Asymptomatic
GSM429260	respiratory syncytial virus challenge sample at T_RSV010	RSV at peak symptoms	T - peak symptoms	RSV010	Asymptomatic
GSM429261	respiratory syncytial virus challenge sample at baseline_RSV011	RSV at baseline	baseline	RSV011	Symptomatic
GSM429262	respiratory syncytial virus challenge sample at T_RSV011	RSV at peak symptoms	T - peak symptoms	RSV011	Symptomatic
GSM429263	respiratory syncytial virus challenge sample at baseline_RSV012	RSV at baseline	baseline	RSV012	Symptomatic
GSM429264	respiratory syncytial virus challenge sample at T_RSV012	RSV at peak symptoms	T - peak symptoms	RSV012	Symptomatic
GSM429265	respiratory syncytial virus challenge sample at baseline_RSV013	RSV at baseline	baseline	RSV013	Asymptomatic
GSM429266	respiratory syncytial virus challenge sample at T_RSV013	RSV at peak symptoms	T - peak symptoms	RSV013	Asymptomatic
GSM429267	respiratory syncytial virus challenge sample at baseline_RSV014	RSV at baseline	baseline	RSV014	Symptomatic
GSM429268	respiratory syncytial virus challenge sample at T_RSV014	RSV at peak symptoms	T - peak symptoms	RSV014	Symptomatic
GSM429269	respiratory syncytial virus challenge sample at baseline_RSV015	RSV at baseline	baseline	RSV015	Asymptomatic
GSM429270	respiratory syncytial virus challenge sample at T_RSV015	RSV at peak symptoms	T - peak symptoms	RSV015	Asymptomatic
GSM429271	respiratory syncytial virus challenge sample at baseline_RSV016	RSV at baseline	baseline	RSV016	Asymptomatic
GSM429272	respiratory syncytial virus challenge sample at T_RSV016	RSV at peak symptoms	T - peak symptoms	RSV016	Asymptomatic
GSM429273	respiratory syncytial virus challenge sample at baseline_RSV017	RSV at baseline	baseline	RSV017	Asymptomatic
GSM429274	respiratory syncytial virus challenge sample at T_RSV017	RSV at peak symptoms	T - peak symptoms	RSV017	Asymptomatic
GSM429275	respiratory syncytial virus challenge sample at baseline_RSV018	RSV at baseline	baseline	RSV018	Asymptomatic
GSM429276	respiratory syncytial virus challenge sample at T_RSV018	RSV at peak symptoms	T - peak symptoms	RSV018	Asymptomatic
GSM429277	respiratory syncytial virus challenge sample at baseline_RSV019	RSV at baseline	baseline	RSV019	Asymptomatic
GSM429278	respiratory syncytial virus challenge sample at T_RSV019	RSV at peak symptoms	T - peak symptoms	RSV019	Asymptomatic
GSM429279	respiratory syncytial virus challenge sample at baseline_RSV020	RSV at baseline	baseline	RSV020	Symptomatic
GSM429280	respiratory syncytial virus challenge sample at T_RSV020	RSV at peak symptoms	T - peak symptoms	RSV020	Symptomatic
GSM429281	Influenza A H3N2 challenge sample at baseline_Flu001	H3N2 at baseline	baseline	Flu001	Symptomatic
GSM429282	Influenza A H3N2 challenge sample at T_Flu001	H3N2 at peak symptoms	T - peak symptoms	Flu001	Symptomatic
GSM429283	Influenza A H3N2 challenge sample at baseline_Flu002	H3N2 at baseline	baseline	Flu002	Asymptomatic
GSM429284	Influenza A H3N2 challenge sample at T_Flu002	H3N2 at peak symptoms	T - peak symptoms	Flu002	Asymptomatic
GSM429285	Influenza A H3N2 challenge sample at baseline_Flu003	H3N2 at baseline	baseline	Flu003	Asymptomatic
GSM429286	Influenza A H3N2 challenge sample at T_Flu003	H3N2 at peak symptoms	T - peak symptoms	Flu003	Asymptomatic
GSM429287	Influenza A H3N2 challenge sample at baseline_Flu004	H3N2 at baseline	baseline	Flu004	Asymptomatic
GSM429288	Influenza A H3N2 challenge sample at T_Flu004	H3N2 at peak symptoms	T - peak symptoms	Flu004	Asymptomatic
GSM429289	Influenza A H3N2 challenge sample at baseline_Flu005	H3N2 at baseline	baseline	Flu005	Symptomatic
GSM429290	Influenza A H3N2 challenge sample at T_Flu005	H3N2 at peak symptoms	T - peak symptoms	Flu005	Symptomatic
GSM429291	Influenza A H3N2 challenge sample at baseline_Flu006	H3N2 at baseline	baseline	Flu006	Symptomatic
GSM429292	Influenza A H3N2 challenge sample at T_Flu006	H3N2 at peak symptoms	T - peak symptoms	Flu006	Symptomatic
GSM429293	Influenza A H3N2 challenge sample at baseline_Flu007	H3N2 at baseline	baseline	Flu007	Symptomatic
GSM429294	Influenza A H3N2 challenge sample at T_Flu007	H3N2 at peak symptoms	T - peak symptoms	Flu007	Symptomatic
GSM429295	Influenza A H3N2 challenge sample at baseline_Flu008	H3N2 at baseline	baseline	Flu008	Symptomatic
GSM429296	Influenza A H3N2 challenge sample at T_Flu008	H3N2 at peak symptoms	T - peak symptoms	Flu008	Symptomatic
GSM429297	Influenza A H3N2 challenge sample at baseline_Flu009	H3N2 at baseline	baseline	Flu009	Asymptomatic
GSM429298	Influenza A H3N2 challenge sample at T_Flu009	H3N2 at peak symptoms	T - peak symptoms	Flu009	Asymptomatic
GSM429299	Influenza A H3N2 challenge sample at baseline_Flu010	H3N2 at baseline	baseline	Flu010	Symptomatic
GSM429300	Influenza A H3N2 challenge sample at T_Flu010	H3N2 at peak symptoms	T - peak symptoms	Flu010	Symptomatic
GSM429301	Influenza A H3N2 challenge sample at baseline_Flu011	H3N2 at baseline	baseline	Flu011	Asymptomatic
GSM429302	Influenza A H3N2 challenge sample at T_Flu011	H3N2 at peak symptoms	T - peak symptoms	Flu011	Asymptomatic
GSM429303	Influenza A H3N2 challenge sample at baseline_Flu012	H3N2 at baseline	baseline	Flu012	Symptomatic
GSM429304	Influenza A H3N2 challenge sample at T_Flu012	H3N2 at peak symptoms	T - peak symptoms	Flu012	Symptomatic
GSM429305	Influenza A H3N2 challenge sample at baseline_Flu013	H3N2 at baseline	baseline	Flu013	Symptomatic
GSM429306	Influenza A H3N2 challenge sample at T_Flu013	H3N2 at peak symptoms	T - peak symptoms	Flu013	Symptomatic
GSM429307	Influenza A H3N2 challenge sample at baseline_Flu014	H3N2 at baseline	baseline	Flu014	Asymptomatic
GSM429308	Influenza A H3N2 challenge sample at T_Flu014	H3N2 at peak symptoms	T - peak symptoms	Flu014	Asymptomatic
GSM429309	Influenza A H3N2 challenge sample at baseline_Flu015	H3N2 at baseline	baseline	Flu015	Asymptomatic
GSM429310	Influenza A H3N2 challenge sample at T_Flu015	H3N2 at peak symptoms	T - peak symptoms	Flu015	Asymptomatic
GSM429311	Influenza A H3N2 challenge sample at baseline_Flu016	H3N2 at baseline	baseline	Flu016	Asymptomatic
GSM429312	Influenza A H3N2 challenge sample at T_Flu016	H3N2 at peak symptoms	T - peak symptoms	Flu016	Asymptomatic
GSM429313	Influenza A H3N2 challenge sample at baseline_Flu017	H3N2 at baseline	baseline	Flu017	Asymptomatic
GSM429314	Influenza A H3N2 challenge sample at T_Flu017	H3N2 at peak symptoms	T - peak symptoms	Flu017	Asymptomatic

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