Sample Set Annotation Tool: Genome-wide analysis of whole blood transcriptional response to Respiratory Syncytial Virus (RSV), Influenza and Rhinovirus lower respiratory tract infection (LRTI) in children. GSE38900 (GPL10558)

Study Design
Assay
Sample Info
Files
Info
Samples
Group Sets
Analysis

Purpose

Analysis of transcriptional profiles in whole blood from children < 2 years of age (and healthy matched controls) with RSV, rhinovirus and influenza infection. The hypothesis tested is that transcriptional profile heterogeneity will reflect patient clinical heterogeneity and that RSV infection induces a distinct host response compared with influenza and rhinovirus infection

Hypothesis

Experimental Design

Total RNA extracted from whole blood (lysed in Tempus tubes) drawn from individual pediatric patients with acute RSV, influenza and Rhinovirus lower respiratory tract infection. A total of 241 samples are analyzed: 135 with acute RSV LRTI, 30 with Rhinovirus LRTI, 16 with influenza LRTI, 39 age-sex matched healthy controls and 21 samples obtained one month after the acute hospitalization in children with RSV.

Experimental Variables

Controls

Methods

Additional Information

Expected Samples:

36 Samples Loaded: 36

Species

Human (Homo sapiens)

Sample Source

Whole Blood

Disease

RSV, Influenza, Rhinovirus

Treatment Protocol

Growth Protocol

Extraction Protocol

Storage Conditions

Sample Set Spreadsheet

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Samples Preview

Sample ID	!Sample Title	Age	Gender	tissue	group
GSM1226237	Columbus healthy control 1	1.2	male	whole blood	Healthy Control
GSM1226238	Columbus healthy control 2	11.83	male	whole blood	Healthy Control
GSM1226239	Columbus healthy control 3	12.27	male	whole blood	Healthy Control
GSM1226240	Columbus healthy control 4	13.6	male	whole blood	Healthy Control
GSM1226241	Columbus healthy control 5	8.83	male	whole blood	Healthy Control

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File
sampleset4000071_sampleannotations_Group.csv Sample Set Spreadsheet
sampleset4000071_sampleannotations_Group.csv Sample Set Spreadsheet

Samples Viewer / Editor

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Sample ID	!Sample Title	Age	Gender	Tissue	Group	Sample group
GSM1226237	Columbus healthy control 1	1.2	male	whole blood	Healthy Control	healthy matched control
GSM1226238	Columbus healthy control 2	11.83	male	whole blood	Healthy Control	healthy matched control
GSM1226239	Columbus healthy control 3	12.27	male	whole blood	Healthy Control	healthy matched control
GSM1226240	Columbus healthy control 4	13.6	male	whole blood	Healthy Control	healthy matched control
GSM1226241	Columbus healthy control 5	8.83	male	whole blood	Healthy Control	healthy matched control
GSM1226242	Columbus healthy control 6	1	male	whole blood	Healthy Control	healthy matched control
GSM1226243	Columbus healthy control 7	1.6	female	whole blood	Healthy Control	healthy matched control
GSM1226244	Columbus healthy control 8	1.93	male	whole blood	Healthy Control	healthy matched control
GSM1226245	Columbus Acute RSV 1	0.37	male	whole blood	RSV	acute Respiratory Syncytial Virus lower respiratory tract infection (RSV LRTI)
GSM1226246	Columbus Acute RSV 2	4.4	male	whole blood	RSV	acute Respiratory Syncytial Virus lower respiratory tract infection (RSV LRTI)
GSM1226247	Columbus Acute RSV 3	1	female	whole blood	RSV	acute Respiratory Syncytial Virus lower respiratory tract infection (RSV LRTI)
GSM1226248	Columbus Acute RSV 4	4	male	whole blood	RSV	acute Respiratory Syncytial Virus lower respiratory tract infection (RSV LRTI)
GSM1226249	Columbus Acute RSV 5	6.93	female	whole blood	RSV	acute Respiratory Syncytial Virus lower respiratory tract infection (RSV LRTI)
GSM1226250	Columbus Acute RSV 6	4.6	male	whole blood	RSV	acute Respiratory Syncytial Virus lower respiratory tract infection (RSV LRTI)
GSM1226251	Columbus Acute RSV 7	5	female	whole blood	RSV	acute Respiratory Syncytial Virus lower respiratory tract infection (RSV LRTI)
GSM1226252	Columbus Acute RSV 8	2.53	male	whole blood	RSV	acute Respiratory Syncytial Virus lower respiratory tract infection (RSV LRTI)
GSM1226253	Columbus Acute RSV 9	2.8	male	whole blood	RSV	acute Respiratory Syncytial Virus lower respiratory tract infection (RSV LRTI)
GSM1226254	Columbus Acute RSV 10	3.9	male	whole blood	RSV	acute Respiratory Syncytial Virus lower respiratory tract infection (RSV LRTI)
GSM1226255	Columbus Acute RSV 11	2.93	male	whole blood	RSV	acute Respiratory Syncytial Virus lower respiratory tract infection (RSV LRTI)
GSM1226256	Columbus Acute RSV 12	0.53	male	whole blood	RSV	acute Respiratory Syncytial Virus lower respiratory tract infection (RSV LRTI)
GSM1226257	Columbus Acute RSV 13	1.33	female	whole blood	RSV	acute Respiratory Syncytial Virus lower respiratory tract infection (RSV LRTI)
GSM1226258	Columbus Acute RSV 14	5.33	female	whole blood	RSV	acute Respiratory Syncytial Virus lower respiratory tract infection (RSV LRTI)
GSM1226259	Columbus Acute RSV 15	2.73	male	whole blood	RSV	acute Respiratory Syncytial Virus lower respiratory tract infection (RSV LRTI)
GSM1226260	Columbus Acute RSV 16	1.6	female	whole blood	RSV	acute Respiratory Syncytial Virus lower respiratory tract infection (RSV LRTI)
GSM1226261	Columbus Acute RSV 17	12.77	female	whole blood	RSV	acute Respiratory Syncytial Virus lower respiratory tract infection (RSV LRTI)
GSM1226262	Columbus Acute RSV 18	0.87	male	whole blood	RSV	acute Respiratory Syncytial Virus lower respiratory tract infection (RSV LRTI)
GSM1226263	Columbus Acute RSV 19	3.03	female	whole blood	RSV	acute Respiratory Syncytial Virus lower respiratory tract infection (RSV LRTI)
GSM1226264	Columbus Acute RSV 20	2.9	male	whole blood	RSV	acute Respiratory Syncytial Virus lower respiratory tract infection (RSV LRTI)
GSM1226265	Columbus Acute RSV 21	2.27	female	whole blood	RSV	acute Respiratory Syncytial Virus lower respiratory tract infection (RSV LRTI)
GSM1226266	Columbus Acute RSV 22	4.07	male	whole blood	RSV	acute Respiratory Syncytial Virus lower respiratory tract infection (RSV LRTI)
GSM1226267	Columbus Acute RSV 23	3.33	female	whole blood	RSV	acute Respiratory Syncytial Virus lower respiratory tract infection (RSV LRTI)
GSM1226268	Columbus Acute RSV 24	1.5	female	whole blood	RSV	acute Respiratory Syncytial Virus lower respiratory tract infection (RSV LRTI)
GSM1226269	Columbus Acute RSV 25	2	male	whole blood	RSV	acute Respiratory Syncytial Virus lower respiratory tract infection (RSV LRTI)
GSM1226270	Columbus Acute RSV 26	1.7	male	whole blood	RSV	acute Respiratory Syncytial Virus lower respiratory tract infection (RSV LRTI)
GSM1226271	Columbus Acute RSV 27	8.43	male	whole blood	RSV	acute Respiratory Syncytial Virus lower respiratory tract infection (RSV LRTI)
GSM1226272	Columbus Acute RSV 28	3.73	male	whole blood	RSV	acute Respiratory Syncytial Virus lower respiratory tract infection (RSV LRTI)

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